Determination of the Enantiomeric Composition of Chiral Aminoalcohols Using Chiral Derivatization and Reversed-Phase Liquid Chromatography
- 1 February 1986
- journal article
- research article
- Published by Informa UK Limited in Journal of Liquid Chromatography
- Vol. 9 (2-3), 673-681
- https://doi.org/10.1080/01483918608076660
Abstract
A variety of racemic aminoalcohols were derivatized with 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate. The resulting two diastereomeric derivatives of each racemate were separated on octadecylsilane liquid-chromatographic columns using methanol-water mixtures as mobile phase and detection at 254 nm. The procedure is simple, rapid and convenient, and may be generally applicable to the determination of the enantiomeric composition of aminoalcohols.Keywords
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