Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67
- 31 May 2006
- journal article
- Published by Elsevier BV in Oral Oncology
- Vol. 42 (5), 475-480
- https://doi.org/10.1016/j.oraloncology.2005.09.012
Abstract
A small proportion of cases diagnosed as oral lichen planus (OLP) and oral lichenoid lesions (OLL) can undergo malignant transformation. Some authors, however, stand that only dysplastic lichenoid lesions, not true OLP, have the potential to progress to oral squamous cell carcinoma (OSCC). The histologic diagnosis is a subjective resource and is not always accurate in differentiating OLP from OLL. Thus, this study attempted to evaluate the malignant potential of lesions diagnosed as OLP and as OLL without dysplasia. The Streptavidin-biotin method of immunohistochemistry was used for the staining with p53 and Ki67 in 22 cases of OLP and 27 cases diagnosed as OLL. Ki67 immunoexpression was not statistically different between OLP and OLL (p = 0.353), but, p53 staining showed a significant contrast (p = 0.036). A higher average of staining was detected in the group of OLP. The study showed that apparently a diagnosis of OLP or OLL makes no difference for the patient regarding malignant transformation, although in OLP p53 showed a higher index of expression, probably related to the intensity of inflammatory infiltrate.Keywords
This publication has 22 references indexed in Scilit:
- Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: Use of fuzzy neural networksInternational Journal of Cancer, 2005
- HPV DNA in clinically different variants of oral leukoplakia and lichen planusOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2004
- Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesionsMedical Microbiology and Immunology, 2003
- Observer variability in the histologic assessment of oral premalignant lesionsJournal of Oral Pathology & Medicine, 1995
- The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.The Journal of cell biology, 1993
- Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53Science, 1990
- Oral lichen planus – a demographic studyCommunity Dentistry and Oral Epidemiology, 1987
- Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinomaJournal of Oral Pathology & Medicine, 1985
- Lichen planus: review and update on pathogenesisJournal of Oral Pathology & Medicine, 1985
- Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferationInternational Journal of Cancer, 1983