Disturbances of apoptotic cell clearance in systemic lupus erythematosus
Open Access
- 1 January 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 13 (1), 202
- https://doi.org/10.1186/ar3206
Abstract
Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in various tissues including germinal centers. In the present review, we discuss the danger signals released by apoptotic cells, their triggering of inflammatory responses, and the breakdown of B-cell tolerance. We also review the pathogenic role of apoptotic cell clearance in systemic lupus erythematosus.Keywords
This publication has 65 references indexed in Scilit:
- Programmed cell clearance: Molecular regulation of the elimination of apoptotic cell corpses and its role in the resolution of inflammationBiochemical and Biophysical Research Communications, 2010
- Impairment of neutrophil extracellular trap degradation is associated with lupus nephritisProceedings of the National Academy of Sciences of the United States of America, 2010
- T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient miceProceedings of the National Academy of Sciences of the United States of America, 2010
- Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearanceNature, 2009
- MerTK regulates thymic selection of autoreactive T cellsProceedings of the National Academy of Sciences of the United States of America, 2009
- Function and role of microparticles in various clinical settingsThrombosis Research, 2008
- Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLEThe Journal of Experimental Medicine, 2008
- Immunobiology of the TAM receptorsNature Reviews Immunology, 2008
- Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cellsThe Journal of cell biology, 2008
- TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic CellsImmunity, 2007