Pain, catastrophizing, and depression in the rheumatic diseases
Top Cited Papers
- 1 February 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Rheumatology
- Vol. 7 (4), 216-224
- https://doi.org/10.1038/nrrheum.2011.2
Abstract
Persistent and disabling pain is the hallmark of osteoarthritis, rheumatoid arthritis, fibromyalgia, and various other rheumatologic conditions. However, disease severity (as measured by 'objective' indices such as those that employ radiography or serology) is only marginally related to patients' reports of pain severity, and pain-related presentation can differ widely between individuals with ostensibly similar conditions (for example, grade 4 osteoarthritis of the knee). Increasing evidence in support of the biopsychosocial model of pain suggests that cognitive and emotional processes are crucial contributors to inter-individual differences in the perception and impact of pain. This Review describes the growing body of literature relating depression and catastrophizing to the experience of pain and pain-related sequelae across a number of rheumatic diseases. Depression and catastrophizing are consistently associated with the reported severity of pain, sensitivity to pain, physical disability, poor treatment outcomes, and inflammatory disease activity, and potentially with early mortality. A variety of pathways, from cognitive to behavioral to neurophysiological, seem to mediate these deleterious effects. Collectively, depression and catastrophizing are critically important variables in understanding the experience of pain in patients with rheumatologic disorders. Pain, depression, and catastrophizing might all be uniquely important therapeutic targets in the multimodal management of a range of such conditions.Keywords
This publication has 120 references indexed in Scilit:
- Situational Versus Dispositional Measurement of Catastrophizing: Associations With Pain Responses in Multiple SamplesThe Journal of Pain, 2010
- Patient‐physician discordance in assessments of global disease severity in rheumatoid arthritisArthritis Care & Research, 2010
- Catastrophizing delays the analgesic effect of distractionPain, 2010
- Tai Chi is effective in treating knee osteoarthritis: A randomized controlled trialArthritis Care & Research, 2009
- No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorderPain, 2009
- Association between C-reactive protein and depressive symptoms in women with rheumatoid arthritisBiological Psychology, 2009
- Childhood psychosocial stressors and adult onset arthritis: Broad spectrum risk factors and allostatic loadPain, 2009
- A randomized trial of behavioral physical therapy interventions for acute and sub-acute low back pain (NCT00373867)Pain, 2008
- Association of catastrophizing with interleukin-6 responses to acute painPain, 2008
- Evidence for a biopsychosocial influence on shoulder pain: Pain catastrophizing and catechol- O -methyltransferase (COMT) diplotype predict clinical pain ratingsPain, 2008