Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill.
- 1 January 2013
- journal article
- research article
- Published by The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS in TURKISH JOURNAL OF CHEMISTRY
- Vol. 37 (4), 619-632
- https://doi.org/10.3906/kim-1303-25
Abstract
The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.This publication has 20 references indexed in Scilit:
- Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activitiesFood and Chemical Toxicology, 2010
- Sesterterpenoids and Other Constituents of Salvia sahendicaJournal of Natural Products, 2010
- Variation of the Chemical Profile and Antioxidant Behavior ofRosmarinus officinalisL. andSalvia fruticosaMiller Grown in GreeceJournal of Agricultural and Food Chemistry, 2008
- 13C and 1H NMR signal assignments of some new synthetic dehydroabietic acid derivativesMagnetic Resonance in Chemistry, 2008
- Cytotoxic Activity of Some AnatolianSalvia. Extracts and Isolated Abietane DiterpenoidsPharmaceutical Biology, 2008
- Antioxidant abietane diterpenoids from Salvia barrelieriFood Chemistry, 2007
- Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South BrazilFood Chemistry, 2007
- Constituents ofSalvia microphyllaNatural Product Research, 2006
- Volatile Metabolites from Salvia fruticosa as Antifungal Agents in Soilborne PathogensJournal of Agricultural and Food Chemistry, 2003
- Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disordersPhytotherapy Research, 2003