Dispersion of DMPC Liposomes in Contact Lenses for Ophthalmic Drug Delivery
- 1 January 2005
- journal article
- research article
- Published by Taylor & Francis Ltd in Current Eye Research
- Vol. 30 (12), 1071-1080
- https://doi.org/10.1080/02713680500346633
Abstract
Approximately 90% of all ophthalmic drug formulations are now applied as eyedrops. Although eyedrops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters the bloodstream and may cause side effects. To reduce drug loss and side effects, it is proposed to encapsulate the ophthalmic drug formulations in liposomes and to disperse the drug-laden liposomes in the lens material. Upon insertion into the eye, the liposome-laden lens will slowly release the drug into the pre-lens (the film between the air and the lens) and the post-lens (the film between the cornea and the lens) tear films and thus provide drug delivery for extended periods of time. This paper focuses on dispersing dimyristoyl phosphatidylcholine (DMPC) liposomes in poly-2-hydroxyethyl methacrylate (p-HEMA) hydrogels, which are a common contact lens material. The results of this study show that the p-HEMA gels loaded with liposomes are transparent and that these gels release drugs for a period of about 8 days. Contact lenses made of particle-laden gels are expected to deliver drugs at therapeutic levels for a few days. The delivery rates can be tailored by controlling the particle and the drug loading.Keywords
This publication has 13 references indexed in Scilit:
- Improved penetration of aminoglycosides and fluoroquinolones into the aqueous humour of patients by means of Acuvue contact lensesEuropean Journal of Clinical Pharmacology, 1999
- Tear mixing under a soft contact lens: effects of lens diameterAmerican Journal of Ophthalmology, 1999
- Ophthalmic drug delivery systems—Recent advancesProgress in Retinal and Eye Research, 1998
- A 6‐month, randomized, double‐masked comparison of latanoprost with timolol in patients with open angle glaucoma or ocular hypertensionActa Ophthalmologica Scandinavica, 1996
- Ocular drug delivery conventional ocular formulationsAdvanced Drug Delivery Reviews, 1995
- Ocular absorption following topical deliveryAdvanced Drug Delivery Reviews, 1995
- A Comparison of the Clinical Variations of the Iridocorneal Endothelial SyndromeAmerican Journal of Ophthalmology, 1989
- Ultrastructural Effects of Topical Timolol on the Rabbit CorneaAmerican Journal of Ophthalmology, 1983
- Pilocarpine dispensation for the soft hydrophilic contact lens.British Journal of Ophthalmology, 1975
- Management of acute glaucoma with pilocarpine-soaked hydrophilic lens.British Journal of Ophthalmology, 1974