Roles of BCL6 in normal and transformed germinal center B cells
- 13 April 2012
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 247 (1), 172-183
- https://doi.org/10.1111/j.1600-065x.2012.01112.x
Abstract
BCL6 is a transcriptional repressor required in mature B cells during the germinal center (GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at transcriptional and post-transcriptional levels. BCL6 prevents premature activation and differentiation of GC B cells and provides an environment tolerant of the DNA breaks associated with immunoglobulin gene remodeling mechanisms involved in the production of high-affinity antibodies of different isotypes. The critical functions exerted by BCL6 during normal B-cell development can be hijacked by the malignant transformation process. Indeed, BCL6 is targeted by genetic aberrations and acts as an oncogene in GC-derived lymphomas. The aberrations affecting BCL6 interfere with the multiple levels of regulation that grant a fine tuning of BCL6 expression and activity in physiologic conditions. This review summarizes the current knowledge on BCL6 function and its role in lymphomagenesis.Keywords
This publication has 80 references indexed in Scilit:
- FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomasNature, 2012
- Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular ZoneImmunity, 2011
- The impact of acetylation and deacetylation on the p53 pathwayProtein & Cell, 2011
- Inactivating mutations of acetyltransferase genes in B-cell lymphomaNature, 2011
- A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In VivoCancer Cell, 2010
- A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomasNature Medicine, 2009
- BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cellsBlood Cells, Molecules, and Diseases, 2008
- Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphomaLeukemia, 2007
- Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomasProceedings of the National Academy of Sciences of the United States of America, 2007
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000