Co-dependents: MR1-restricted MAIT cells and their antimicrobial function
- 26 November 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 11 (1), 14-19
- https://doi.org/10.1038/nrmicro2918
Abstract
Mucosal-associated invariant T (MAIT) cells are a unique T cell subset in mammals. They are present at high frequencies at mucosal tissue sites and have an intrinsic capacity to respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites. The striking evolutionary conservation in both the MR1 molecule and the MAIT T cell receptor suggests that strong selective pressures maintain this T cell pattern recognition system which detects microbial infection.Keywords
This publication has 49 references indexed in Scilit:
- Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorThe Journal of Experimental Medicine, 2012
- Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cellsBlood, 2011
- The origins of vertebrate adaptive immunityNature Reviews Immunology, 2010
- Evolution and immunityImmunology, 2010
- Antimicrobial activity of mucosal-associated invariant T cellsNature Immunology, 2010
- Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleenVeterinary Research, 2010
- T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell RepertoireImmunity, 2009
- MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolutionProceedings of the National Academy of Sciences of the United States of America, 2009
- MR1 uses an endocytic pathway to activate mucosal-associated invariant T cellsThe Journal of Experimental Medicine, 2008
- Why study the evolution of immunity?Nature Immunology, 2007