Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
- 20 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 14 (3), 221-229
- https://doi.org/10.1038/ni.2534
Abstract
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets TH2, TH17 and TH22. Here we describe a distinct ILC subset similar to TH1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt+ ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation.Keywords
This publication has 50 references indexed in Scilit:
- The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid CellsImmunity, 2012
- Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunityNature Immunology, 2011
- Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunityJournal of Allergy and Clinical Immunology, 2011
- Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate LymphocytesImmunity, 2010
- Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticityProceedings of the National Academy of Sciences of the United States of America, 2010
- Systemically dispersed innate IL-13–expressing cells in type 2 immunityProceedings of the National Academy of Sciences of the United States of America, 2010
- Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell LineageImmunity, 2010
- Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityNature, 2010
- Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune SystemCell, 2007
- Evidence for discrete stages of human natural killer cell differentiation in vivoThe Journal of Experimental Medicine, 2006