Historical Perspective — Emergence of Influenza A (H1N1) Viruses
- 16 July 2009
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 361 (3), 279-285
- https://doi.org/10.1056/nejmra0904322
Abstract
On April 17, 2009, officials at the Centers for Disease Control and Prevention (CDC) confirmed two cases of swine influenza in children living in neighboring counties in California.1 Here we take a perspective from systems biology to review the series of evolutionary and epidemiologic events, starting in 1918, that led to the emergence of the current swine-origin influenza A (H1N1) strain (S-OIV), which is widely known as swine flu. This article is one of two historical articles on influenza A (H1N1) viruses in this issue of the Journal.2 Our review focuses on the key steps that characterize this viral evolution ( Figure 1 ).This publication has 43 references indexed in Scilit:
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