Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee— a subset analysis
- 21 October 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Advances in Therapy
- Vol. 27 (12), 953-962
- https://doi.org/10.1007/s12325-010-0083-9
Abstract
Twice-daily flavocoxid, a cyclooxygenase and 5-lipoxygenase inhibitor with potent antioxidant activity of botanical origin, was evaluated for 12 weeks in a randomized, double-blind, active-comparator study against naproxen in 220 subjects with moderate-severe osteoarthritis (OA) of the knee. As previously reported, both groups noted a significant reduction in the signs and symptoms of OA with no detectable differences in efficacy between the groups when the entire intent-to-treat population was considered. This post-hoc analysis compares the efficacy of flavocoxid to naproxen in different subsets of patients, specifically those related to age, gender, and disease severity as reported at baseline for individual response parameters.This publication has 18 references indexed in Scilit:
- 90-Day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in ratsFood and Chemical Toxicology, 2010
- Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisoloneExperimental Neurology, 2009
- Flavocoxid, a dual inhibitor of cyclooxygenase and 5‐lipoxygenase, blunts pro‐inflammatory phenotype activation in endotoxin‐stimulated macrophagesBritish Journal of Pharmacology, 2009
- SAFETY EVALUATION OF A COMBINATION, DEFINED EXTRACT OF SCUTELLARIA BAICALENSIS AND ACACIA CATECHUJournal of Food Biochemistry, 2007
- A Medicinal Extract ofScutellaria baicalensisandAcacia catechuActs as a Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase to Reduce InflammationJournal of Medicinal Food, 2007
- Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3)Rheumatology, 2007
- Pathogenesis and management of pain in osteoarthritisThe Lancet, 2005
- Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose‐binding site of the human erythrocyte glucose transporter GLUT1British Journal of Pharmacology, 2003
- Regular review: Medical management of osteoarthritisBMJ, 2000
- An analysis of variance test for normality (complete samples)Biometrika, 1965