Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control
Open Access
- 8 May 2018
- journal article
- research article
- Published by Hindawi Limited in Behavioural Neurology
- Vol. 2018, 1-12
- https://doi.org/10.1155/2018/8420658
Abstract
Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern metabolism transforming connections between various brain regions; therefore, most physicians do not understand the underlying neuropathology of DLB patients. In this study, 18F FDG-PET images and graph-theoretical methods were used to investigate alterations in whole-brain intrinsic functional connectivity in a Chinese DLB group and healthy control (HC) group. This experimental study was performed on 22 DLB patients and 22 HC subjects in Huashan Hospital, Shanghai, China. Experimental results indicate that compared with the HC group, the DLB group has severely impaired small-world network. Compared to those of the HC group, the clustering coefficients of the DLB group were higher and characteristic path lengths were longer, and in terms of global efficiencies, those of the DLB group was also lower. Moreover, four significantly altered regions were observed in the DLB group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (OLF.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). Amongst them, in the DLB group, betweenness centrality became strong in OLF.R, HIP.R, and FFG.L, whereas betweenness centrality became weaker in IFG.R. Finally, IFGoperc.R was selected as a seed and a voxel-wise correlation analysis was performed. Compared to the HC group, the DLB group showed several regions of strengthened connection with IFGoperc.R; these regions were located in the prefrontal cortex and regions of weakened connection were located in the occipital cortex. The results of this paper may help physicians to better understand and characterize DLB patients.Keywords
Funding Information
- Scientific and Technological Innovation Project of Traditional Chinese Medicine in Shanghai (ZYKC201602002, 16YF1415400, 17JC1401600, 2016YFC1306500, 2016YFC1306305, 81361120393, 81771483, 81401135, 81671239, 61603236)
This publication has 37 references indexed in Scilit:
- Altered Resting State Brain Networks in Parkinson’s DiseasePLOS ONE, 2013
- BrainNet Viewer: A Network Visualization Tool for Human Brain ConnectomicsPLOS ONE, 2013
- REST: A Toolkit for Resting-State Functional Magnetic Resonance Imaging Data ProcessingPLOS ONE, 2011
- Complex network measures of brain connectivity: Uses and interpretationsNeuroImage, 2010
- Regional aerobic glycolysis in the human brainProceedings of the National Academy of Sciences of the United States of America, 2010
- Functional connectivity density mappingProceedings of the National Academy of Sciences of the United States of America, 2010
- Whole-brain anatomical networks: Does the choice of nodes matter?NeuroImage, 2010
- Parcellation‐dependent small‐world brain functional networks: A resting‐state fMRI studyHuman Brain Mapping, 2008
- Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's DiseaseJournal of Neuroscience, 2008
- Efficiency and Cost of Economical Brain Functional NetworksPLoS Computational Biology, 2007