Lectin binding and desmin staining during bupivicaine‐induced necrosis and regeneration in rat skeletal muscle
- 1 August 1988
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 155 (4), 317-326
- https://doi.org/10.1002/path.1711550407
Abstract
The processes of bupivicaine-induced necrosis and regeneration in rat skeletal muscle have been studied with a panel of biotinylated lectins and by immunohistochemical staining for desmin. The results indicate that the binding of lectins to the periphery of muscle fibres is not altered in necrotic and regenerating fibres at the light microscopic level although abnormal cytoplasmic staining by lectins occurs early in necrosis and is also present during regeneration. Desmin staining is lost at an early stage of necrosis and is present at an early stage of regeneration. Desmin staining in combination with morphometrical assessment of the rate of fusion and growth of regenerating fibres provides a powerful method for evaluating the processes of muscle regeneration in experimental situations.Keywords
This publication has 18 references indexed in Scilit:
- Altered binding of Ricinus communis I lectin by muscle membranes in Duchenne muscular dystrophyJournal of the Neurological Sciences, 1984
- Nonspecific staining of mast cells by avidin-biotin-peroxidase complexes (ABC).Journal of Histochemistry & Cytochemistry, 1983
- Membrane abnormalities in Duchenne muscular dystrophyJournal of the Neurological Sciences, 1983
- Morphometric Comparison of Duchenne’s Muscular Dystrophy and Experimental Bupivacaine MyopathyPublished by Springer Science and Business Media LLC ,1981
- Acridine Orange-Nucleic Acid FluorescenceArchives of Neurology, 1980
- Application of lectin cytochemistry to the study of human neuromuscular diseaseMuscle & Nerve, 1980
- The Lectins: Carbohydrate-Binding Proteins of Plants and AnimalsAdvances in Carbohydrate Chemistry and Biochemistry, 1978
- Lectins: Cell-Agglutinating and Sugar-Specific ProteinsScience, 1972
- ALKALINE PHOSPHATASE-POSITIVE ABNORMAL MUSCLE FIBERS OF HUMANSJournal of Histochemistry & Cytochemistry, 1970
- Denervation changes produced in an innervated skeletal muscle by long-continued treatment with a local anestheticEuropean Journal of Pharmacology, 1968