Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy
Open Access
- 1 July 2013
- journal article
- Published by Taylor & Francis Ltd in OncoImmunology
- Vol. 2 (7), e24720
- https://doi.org/10.4161/onci.24720
Abstract
By analyzing over 2000 samples from a randomized clinical trial, we have recently associated high levels of tumor-infiltrating lymphocytes with an excellent prognosis among triple negative breast cancer patients as well with improved clinical responses to immunogenic chemotherapy among patients bearing HER2 over-expression. These findings suggest that immunomodulation could represent a new approach to treat these aggressive breast cancer subtypes.Keywords
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