The Etiopathogenesis of Parkinson Disease and Suggestions for Future Research. Part I
Open Access
- 1 April 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 66 (4), 251-257
- https://doi.org/10.1097/nen.0b013e3180415e42
Abstract
We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.Keywords
This publication has 76 references indexed in Scilit:
- Parkinsonism, Lrrk2 G2019S, and tau neuropathologyNeurology, 2006
- Lrrk2 and Lewy body diseaseAnnals of Neurology, 2006
- Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic PathologyNeuron, 2004
- Tau gene and Parkinson's disease: a case-control study and meta-analysisJournal of Neurology, Neurosurgery & Psychiatry, 2004
- Tau haplotypes regulate transcription and are associated with Parkinson's diseaseAnnals of Neurology, 2004
- Concurrence of α-synuclein and tau brain pathology in the Contursi kindredActa Neuropathologica, 2002
- Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr α‐synuclein mutationAnnals of Neurology, 2001
- Autosomal recessive juvenile parkinsonism: A key to understanding nigral degeneration in sporadic Parkinson's diseaseNeuropathology, 2000
- Distinctive neuropathology revealed by α-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4pActa Neuropathologica, 2000
- Parkinsonian FeaturesPublished by American Medical Association (AMA) ,1998