Effects of Different Exercise Modes on the Urinary Metabolic Fingerprint of Men with and without Metabolic Syndrome
Open Access
- 26 January 2017
- journal article
- research article
- Published by MDPI AG in Metabolites
- Vol. 7 (1), 5
- https://doi.org/10.3390/metabo7010005
Abstract
Exercise is important in the prevention and treatment of the metabolic syndrome (MetS), a cluster of risk factors that raises morbidity. Metabolomics can facilitate the optimization of exercise prescription. This study aimed to investigate whether the response of the human urinary metabolic fingerprint to exercise depends on the presence of MetS or exercise mode. Twenty-three sedentary men (MetS, n = 9, and Healthy, n = 14) completed four trials: resting, high-intensity interval exercise (HIIE), continuous moderate-intensity exercise (CME), and resistance exercise (RE). Urine samples were collected pre-exercise and at 2, 4, and 24 h for targeted analysis by liquid chromatography-mass spectrometry. Time exerted the strongest differentiating effect, followed by exercise mode and health status. The greatest changes were observed in the first post-exercise samples, with a gradual return to baseline at 24 h. RE caused the greatest responses overall, followed by HIIE, while CME had minimal effect. The metabolic fingerprints of the two groups were separated at 2 h, after HIIE and RE; and at 4 h, after HIIE, with evidence of blunted response to exercise in MetS. Our findings show diverse responses of the urinary metabolic fingerprint to different exercise modes in men with and without metabolic syndrome.Keywords
This publication has 54 references indexed in Scilit:
- Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in HumansCirculation, 2012
- Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic FlexibilityCell Metabolism, 2012
- Novel biomarkers for pre‐diabetes identified by metabolomicsMolecular Systems Biology, 2012
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular diseaseNature, 2011
- Interaction among Skeletal Muscle Metabolic Energy Systems during Intense ExerciseJournal of Nutrition and Metabolism, 2010
- α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic PopulationPLOS ONE, 2010
- Metabolic Signatures of Exercise in Human PlasmaScience Translational Medicine, 2010
- Harmonizing the Metabolic SyndromeCirculation, 2009
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin ResistanceCell Metabolism, 2009
- Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin StudyPLOS ONE, 2007