Glucagon Physiology and Pathophysiology
- 19 August 1971
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 285 (8), 443-449
- https://doi.org/10.1056/nejm197108192850806
Abstract
THE function of pancreatic glucagon has been questioned for several decades, but it now seems probable that glucagon, like insulin, is extremely important in the moment-to-moment control of the homeostasis of glucose, of certain amino acids and perhaps of free fatty acids. Normal alpha-cell function seems essential to optimal glucoregulation, and abnormal alpha-cell function may cause, contribute to or result from a variety of metabolic disorders, the most common being diabetes mellitus.Biologic Opposition of Glucagon and InsulinGlucagon has been shown to have potent glycogenolytic1 and gluconeogenic2 , 3 activity at concentrations within the physiologic range. In addition, it may have . . .Keywords
This publication has 18 references indexed in Scilit:
- Glucagon levels and metabolic effects in fasting manJCI Insight, 1970
- The Organ of Langerhans in New PerspectiveThe American Journal of the Medical Sciences, 1970
- Fatty acids and the release of glucagon from isolated guinea-pig islets of langerhans incubated in vitroBiochimica et Biophysica Acta (BBA) - General Subjects, 1970
- Studies of pancreatic alpha cell function in normal and diabetic subjectsJCI Insight, 1970
- Alanine: Key Role in GluconeogenesisScience, 1970
- The gastrointestinal stimulus to insulin releaseJCI Insight, 1969
- The role of aminogenic glucagon secretion in blood glucose homeostasisJCI Insight, 1969
- Effect of plasma free fatty acids on plasma glucagon and serum insulin concentrationsMetabolism, 1968
- Stimulation of insulin secretion by amino acids.JCI Insight, 1966
- HORMONE-FUEL INTERRELATIONSHIPS DURING FASTINGJCI Insight, 1965