Antibodies to endotoxin core in sudden infant death syndrome.
Open Access
- 1 February 1994
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 70 (2), 95-98
- https://doi.org/10.1136/adc.70.2.95
Abstract
To assess the possible role of endotoxaemia in the pathogenesis of sudden infant death syndrome (SIDS), antibodies to endotoxin core (EndoCAb), which have previously been shown to be depressed by systemic endotoxaemia, were measured. IgG and IgM EndoCAb and total serum IgG and IgM were measured in serum samples from 25 children who had died from SIDS and 164 control children under 1 year of age. Twelve (48%) of the 25 children who had died from SIDS had no detectable IgG EndoCAb compared with 28 (17%) of the 164 control children, and this difference was concentrated in children aged less than 3 months. There was no significant difference between the two groups in the percentage of children with no IgM EndoCAb, nor in the total IgG and IgM concentrations. For IgM EndoCAb, the younger children who had died from SIDS had higher concentrations than the controls. These results suggest that, in children who have died from SIDS, due to either unusually early or severe exposure to endotoxin, maternal IgG EndoCAb have been depleted and early IgM EndoCAb triggered.Keywords
This publication has 8 references indexed in Scilit:
- A pathologist's perspective on the sudden infant death syndrome--1991.1992
- Possible mechanisms responsible for the sudden infant death syndromeJournal of Paediatrics and Child Health, 1991
- Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock.1989
- Prevention of endotoxaemia by non-absorbable antibiotics in heat stress.Journal of Clinical Pathology, 1987
- Hypothesis: Common bacterial toxins are a possible cause of the sudden infant death syndromeMedical Hypotheses, 1987
- OVERHEATING AND COT DEATHThe Lancet, 1984
- Sudden and unexpected death in infants: I. Gamma globulin levels in the serumThe Journal of Pediatrics, 1963