Targeting Antigens to Dendritic Cell Receptors for Vaccine Development
Open Access
- 8 October 2013
- journal article
- review article
- Published by Hindawi Limited in Journal of Drug Delivery
- Vol. 2013, 1-22
- https://doi.org/10.1155/2013/869718
Abstract
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen to cell surface molecules on DCs that efficiently channel the antigen into endocytic compartments for loading onto MHC molecules and stimulation of T-cell responses. The most attractive cell surface receptors, expressed on DCs used as targets for antigen delivery for cancer and other diseases, are discussed.Keywords
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