Brain Mitochondrial Function After Ischemia and Hypoxia
- 1 December 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 29 (6), 408-416
- https://doi.org/10.1001/archneur.1973.00490300070009
Abstract
The effect of "compression ischemia" on brain mitochondrial activity was examined in 61 rabbits. We found that (1) the respiratory control ratio was significantly decreased only after 30 and 40 minutes of compression ischemia due to a decrease in state 3 and an increase in state 4 respiration; (2) heavy uncoupling of respiration occurred only after 40 minutes of compression ischemia; (3) uncoupler-activated adenosine triphosphatase (ATPase) was not impaired even after 40 minutes of ischemia, but spontaneous ATPase activity increased significantly; (4) secondary deterioration of mitochondrial function after circulatory recovery did not occur even with severe hypercapnia and hypocapnia in the recovery period as long as the cerebral perfusion pressure was maintained. The findings suggest that alterations in constituents of the cell other than the mitochondria are responsible for irreversible brain damage following brief periods of total cerebral ischemia.Keywords
This publication has 19 references indexed in Scilit:
- The Effect of Vascular Perfusion on the Functional and Morphological Sequelae of Transient Cerebral IschemiaPublished by Springer Science and Business Media LLC ,1971
- The effect of intravascular saline perfusion on the sequelae of transient cerebral ischemiaActa Neuropathologica, 1971
- The Influence of an Increased Intracranial Pressure on the Lactate, Pyruvate, Bicarbonate, Phosphocreatine, ATP, ADP and AMP Concentrations of the Cerebral Cortex of DogsActa Physiologica Scandinavica, 1970
- Recovery of Neuronal Function after Prolonged Cerebral IschemiaScience, 1970
- The effect of ischemia on sensorimotor cortex of catZeitschrift für Neurologie, 1970
- Energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiersBiochemistry, 1968
- Acute intracranial hypertension—An experimental investigationBrain Research, 1967
- Acute intracranial hypertension, cerebral blood flow, and the EEGElectroencephalography and Clinical Neurophysiology, 1966
- Anoxia of Canine Brain Without DamageJAMA, 1963
- Studies on bacterial photophosphorylation III. A sensitive and rapid method of determination of photophosphorylationBiochimica et Biophysica Acta, 1962