Ouabain and Erythrocyte-Ghost Adenosine Triphosphatase
- 1 February 1971
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 24 (2), 187-190
- https://doi.org/10.1001/archneur.1971.00480320115012
Abstract
An adenosine triphosphatase (ATPase) of erythrocyte ghosts from all six patients with Duchenne dystrophy and three of six patients with limb-girdle dystrophy was stimulated by 10-4 molar ouabain but inhibited by the same concentration of ouabain in 11 normal subjects, one patient with Becker dystrophy, and eight other neurological or muscular disorders. The inhibited response was also observed in two possible carriers of Duchenne dystrophy. The abnormality of erythrocyte ghost ATPase in patients with Duchenne dystrophy was not related to age, disability, or serum creatine phosphokinase. The mechanism of the abnormality of ATPase in erythrocyte ghosts from all patients with Duchenne dystrophy and some patients, but not all, with limb-girdle dystrophy is not known (24:187-200, 1971). Key Words.— Ouabain, erythrocyte-ghost ATPase, membrane ATPase, sodium-potassium-ATPase, human muscular dystrophies, Duchenne dystrophy, limb-girdle dystrophy.This publication has 4 references indexed in Scilit:
- Sodium‐potassium adenosine triphosphate in diseased muscleNeurology, 1969
- Adenosine Triphosphatase and MyopathyScience, 1969
- Erythrocyte Abnormality in Human MyopathyScience, 1967
- CHANGES IN MUSCLE STRUCTURE IN DYSTROPHIC PATIENTS, CARRIERS AND NORMAL SIBLINGS SEEN BY ELECTRON MICROSCOPY; CORRELATION WITH LEVELS OF SERUM CREATINEPHOSPHOKINASE (CPK)*Annals of the New York Academy of Sciences, 1966