The identification of the major diazotizable metabolite of 4:4′-diaminodiphenyl sulphone in rabbit urine
- 1 July 1956
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 63 (3), 406-408
- https://doi.org/10.1042/bj0630406
Abstract
The metabolite of 4:4''-diaminodiphenyl sulphone (DADPS) was identified as a glucuronic acid conjugate. One molecule of DADPS is combined with 1 of the acid, and ionophoresis shows that the carboxyl group of the acid is free. The metabolite is acid-labile and breaks down to glucuronic acid and DADPS. The conjugation is therefore probably between the aldehydic C and the N of 1 of the amino groups, and the linkage may be either that of an anil or an N-glucosiduronic structure. The metabolite was synthesized.Keywords
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