Corticothalamic Feedback Controls Sleep Spindle Duration In Vivo
- 22 June 2011
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 31 (25), 9124-9134
- https://doi.org/10.1523/jneurosci.0077-11.2011
Abstract
Spindle oscillations are commonly observed during stage 2 of non-rapid eye movement sleep. During sleep spindles, the cerebral cortex and thalamus interact through feedback connections. Both initiation and termination of spindle oscillations are thought to originate in the thalamus based on thalamic recordings and computational models, although some in vivo results suggest otherwise. Here, we have used computer modeling and in vivo multisite recordings from the cortex and the thalamus in cats to examine the involvement of the cortex in spindle oscillations. We found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.This publication has 63 references indexed in Scilit:
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