Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship
- 26 August 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 127 (4), 647-660
- https://doi.org/10.1007/s00702-019-02067-z
Abstract
Sleep disturbances and chronic pain are considered public health concerns. They are frequently associated, and the direction of its relationship and possible mechanisms underlying it are frequently debated. The exploration of the sleep–pain association is of great clinical interest to explore in order to steer potential therapeutic avenues, accommodate the patient’s experience, and adapt the common practice of health professionals. In this review, the direction between sleep–pain in adult and pediatric populations will be discussed. Moreover, the possible mechanisms contributing to this relationship as endogenous pain modulation, inflammation, affect, mood and other states, the role of different endogenous substances (dopamine, orexin, melatonin, vitamin D) as well as other lesser known such as cyclic alternating pattern among others, will be explored. Finally, directions for future studies on this area will be discussed, opening up to the addition of tools such as brain imaging (e.g., fMRI), electrophysiology and non-invasive brain stimulation techniques. Such resources paired with artificial intelligence are key to personalized medicine management for patients facing pain and sleep interacting conditions.Keywords
This publication has 174 references indexed in Scilit:
- Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human BrainJournal of Neuroscience, 2012
- Pain sensitivity and modulation in primary insomniaEuropean journal of pain, 2012
- REM sleep: A biological and psychological paradoxSleep Medicine Reviews, 2011
- What is this thing called pain?JCI Insight, 2010
- Sleep loss and inflammationBest Practice & Research Clinical Endocrinology & Metabolism, 2010
- Sleep continuity and architecture: Associations with pain‐inhibitory processes in patients with temporomandibular joint disorderEuropean journal of pain, 2009
- Pain catastrophizing: a critical reviewExpert Review of Neurotherapeutics, 2009
- Experimental muscle pain impairs descending inhibitionPain, 2008
- The metabolic consequences of sleep deprivationSleep Medicine Reviews, 2007
- Cytokines, Inflammation, and PainInternational Anesthesiology Clinics, 2007