Immune and inflammatory pathways in NASH
Open Access
- 30 August 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Hepatology International
- Vol. 7 (S2), 771-781
- https://doi.org/10.1007/s12072-013-9468-6
Abstract
Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.Keywords
This publication has 102 references indexed in Scilit:
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during ApoptosisImmunity, 2012
- Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in miceHepatology, 2011
- The InflammasomesCell, 2010
- Accumulation of natural killer T cells in progressive nonalcoholic fatty liver diseaseHepatology, 2010
- Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and managementHepatology, 2008
- Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cellsJournal of Hepatology, 2008
- Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin ResistanceCell Metabolism, 2008
- Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitisJournal of Hepatology, 2007
- Pathogen Recognition and Innate ImmunityCell, 2006
- Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3Cell, 2005