Network Medicine — From Obesity to the “Diseasome”
- 26 July 2007
- journal article
- editorial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 357 (4), 404-407
- https://doi.org/10.1056/nejme078114
Abstract
A recent study reported that among people who carried a single copy of the high-risk allele for the FTO gene, which is associated with fat mass and obesity, the risk of obesity increased by 30%. The risk of obesity increased by 67% among people who carried two alleles, and on average they gained 3.0 kg (6.6 lb) or more.1 Given that approximately one sixth of the population of European descent is homozygous for this allele, this link between the FTO gene and obesity appears to be one of the strongest genotype–phenotype associations detected by modern genome-screening techniques.This publication has 8 references indexed in Scilit:
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