Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme
- 1 March 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (3), 306-308
- https://doi.org/10.1021/np960654e
Abstract
As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH-CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretation of spectral data and X-ray analysis. Daleformis (1) inhibited ECE with an IC50 of 9 microM.Keywords
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