Perinatal outcomes following transfer of human blastocysts vitrified at day 5, 6 and 7
Open Access
- 20 October 2009
- journal article
- Vol. 6, 4
Abstract
Little information is available on perinatal outcome of cryopreserved day-7 blastocyst transfer. In the present report, perinatal outcomes for transfers of cryopreserved blastocysts by a vitrification method were examined with respect to the day of blastocyst expansion among on day 5, 6 or 7 before cryopreservation. We investigated 263 cycles of vitrified-warmed blastocyst stage embryo transfer performed between April 2005 and April 2009, which were reviewed retrospectively. There were 144 cycles with day-5 blastocyst, 100 cycles with day-6 blastocyst, and 19 cycles with day-7 blastocyst transfers. There were no differences among the vitrified day-5, day-6 and day-7 blastocyst transfer groups regarding mean number of embryos transferred, pregnancy rate, implantation rate and miscarriage rate. At this time, 71 deliveries have occurred with no reported abnormalities. There were 47 infants from 41 deliveries with day-5 blastocyst, 26 infants from 23 deliveries with day-6 blastocyst, and 8 infants from 7 deliveries with day-7 blastocyst. There were no differences among the three groups in the mean gestational age, preterm delivery rate and mean birth weight. These results indicated that blastocysts have similar inherent viability regardless of whether they develop by day 5, 6 or 7.Keywords
This publication has 13 references indexed in Scilit:
- Vitrified human day-7 blastocyst transfer: 11 casesReproductive BioMedicine Online, 2008
- Zona pellucida removal and vitrified blastocyst transfer outcome: a preliminary studyReproductive BioMedicine Online, 2007
- Cryopreserved embryo transfers suggest that endometrial receptivity may contribute to reduced success rates of later developing embryosFertility and Sterility, 2006
- Freeze–thaw programmes rescue the implantation of day 6 blastocystsReproductive BioMedicine Online, 2005
- Blastocyst culture after repeated failure of cleavage-stage embryo transfers: A comparison of day 5 and day 6 transfersFertility and Sterility, 2005
- Comparison of open and closed methods for vitrification of human embryos and the elimination of potential contaminationReproductive BioMedicine Online, 2005
- Blastocoele collapse by micropipetting prior to vitrification gives excellent survival and pregnancy outcomes for human day 5 and 6 expanded blastocystsHuman Reproduction, 2004
- A prospective, randomized study: day 3 versus hatching blastocyst stageHuman Reproduction, 2004
- Dizygotic twin delivery following in vitro fertilization and transfer of thawed blastocysts cryopreserved at day 6 and 7Fertility and Sterility, 2003
- Vitrification of human blastocysts using cryoloops: clinical outcome of 223 cyclesHuman Reproduction, 2003