STUDIES ON THE IN VITRO AXENIC DEVELOPMENT OF TRICHINELLA SPIRALIS: II. PRELIMINARY EXPERIMENTS ON THE EFFECTS OF FARNESOL, CHOLESTEROL, AND AN INSECT EXTRACT

Abstract

Farnesol inhibited the development of Trichinella spiralis larvae in vitro; the degree of inhibition was proportional to the concentration of farnesol in the medium. Cholesterol increased the rate of survival of the larvae, but had no effect on their development. Acetone-soluble extract of late larvae and pupae of Galleria mellonella, believed to contain some ecdysone, in a high concentration inhibited the development of the larvae, but in low concentrations promoted complete exsheathment in some cases. The only other factor which had thus far been observed to promote complete exsheathment was CO₂ at high tensions.