Antiproliferative and antioxidant activity of Aegle marmelos (Linn.) leaves in Dalton′s Lymphoma Ascites transplanted mice

Abstract

Objective: The present investigation was performed to evaluate the antiproliferative and antioxidant activity of Aegle marmelos leaves in Dalton's Lymphoma Ascites (DLA)-bearing mice. Materials and Methods: The DLA cells maintained in vivo in Swiss albino mice were used for developing ascitic tumor in mice by intraperitoneal transplantation. The standardized 50% ethanolic extract of A. marmelos leaves (AMEE) was administered intraperitoneally in dose levels 200 and 400 mg/kg, after 24 hours of tumor inoculation in mice for two weeks. Results: The AMEE treatment significantly prevented (PA. marmelos exhibits strong antitumor and antioxidant activities in DLA-bearing mice.