Cocaine and Metabolites in Human Graying Hair: Pigmentary Relationship
- 1 January 1996
- journal article
- Published by Informa UK Limited in Journal of Toxicology: Clinical Toxicology
- Vol. 34 (6), 685-690
- https://doi.org/10.3109/15563659609013829
Abstract
Objective: To assess differences in the binding of cocaine, cocaethylene, and benzoylecgonine among pigmented and senile white hairs of the graying human cocaine abuser. Design: A sheath of graying hair in the region around the apex of the head was gathered between the thumb and index finger then cut and removed about 2 mm proximal to the scalp. The graying hair was divided into pigmented and senile white of equal weights and lengths and then analyzed by gas chromatography/mass spectrometry chemical ionization. Twenty-nine such pairs were analyzed. Subjects: Male cocaine abusers, ages 33-55 years hospitalized for substance abuse. Informed consent was obtained and confidentiality assured. Main Outcome Measures: Concentrations of cocaine, cocaethylene and benzoylecgonine in ng were assessed for each of 29 paired hair samples by gas chromatography/mass spectrometry chemical ionization. Results: There were statistically significant differences between pigmented and senile white sections of paired samples. Cocaine (ng/mg hair, mean ± SD) was 31.5 ±30.2 for pigmented hair vs 14.9 ± 19.8 for senile white portions; (p <0.0001). Cocaethylene (ng/mg hair, mean ± SD) 3.22 ±5.0 (pigmented) vs 0.52 ±0.88 (senile white); (p < 0.0016). Benzoylecgonine (ng/mg hair, mean ± SD) 5.1 ± 5.3 (pigmented) vs 3.9 ± 4.8 (senile white); (p < 0.005). Conclusion: Melaninated pigmented hair seems to bind more cocaine, cocaethylene and benzoylecgonine than white hair in the same subject.Keywords
This publication has 13 references indexed in Scilit:
- TheIn VitroDifferential Binding of Benzoylecgonine to Pigmented Human Hair SamplesJournal of Toxicology: Clinical Toxicology, 1994
- External contamination of hair by cocaine: an issue in forensic interpretationForensic Science International, 1993
- An evaluation of patterns of racial bias in hair assays for cocaine: black and white arrestees comparedForensic Science International, 1993
- The occurrence of cocaine, heroin and metabolites in hair of drug abusersForensic Science International, 1993
- Hair analysis — perspectives and limits of a proposed forensic method of proof: a reviewForensic Science International, 1993
- Hair Melanins and Hair Color: Ultrastructural and Biochemical Aspects.Journal of Investigative Dermatology, 1993
- Testing Human Hair for Drugs of Abuse. II. Identification of Unique Cocaine Metabolites in Hair of Drug Abusers and Evaluation of Decontamination ProceduresJournal of Analytical Toxicology, 1991
- Hair Analysis for Drugs of AbuseJournal of Forensic Sciences, 1989
- The effect of age and hair colour on human hairbulb tyrosinase activityBritish Journal of Dermatology, 1987
- Electron Microscope Studies on Pigment Formation in Human Hair FolliclesPublished by Elsevier BV ,1959