Erythrocyte and Platelet Phospholipid Fatty Acids as Markers of Advanced Non-Small Cell Lung Cancer: Comparison with Serum Levels of Sialic Acid, TPS and Cyfra 21-1
- 1 January 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Cancer Investigation
- Vol. 26 (4), 407-418
- https://doi.org/10.1080/07357900701788114
Abstract
The phospholipid fatty acid profiles of erythrocytes and platelets from fifty patients with advanced non-small cell lung cancer were investigated using gas chromatography/mass spectrometry, followed by “ROC” curves analysis to gain novel biomarker information. Sialic acid and cytokeratins were also examined. Potentially useful fatty acid markers: Erythrocytes: phosphatidylcholine, 18:2n6 and 20:4n6; phosphatidylethanolamine, 22:4n6 and 22:6n3 + 24:1n9. Platelets: phosphatidylcholine, 22.0; phosphatidylethanolamine, 22:5n3 + 24:0. At the cut-off value to obtain maximum accuracy, the best biomarkers were found in platelets: phosphatidylserine + phosphatidylinositol (PS + PI), 21:0; sphyngomyelin: 20:1n9 and 22:1n9. All these fatty acids showed similar/higher diagnostic yields than the commonly used markers sialic acid or cytokeratins.Keywords
This publication has 33 references indexed in Scilit:
- Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS‐LDAFEBS Letters, 2006
- Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stressChemico-Biological Interactions, 2006
- A medical bioinformatics approach for metabolic disorders: Biomedical data prediction, modeling, and systematic analysisJournal of Biomedical Informatics, 2006
- Comparison of Changes in Erythrocyte and Platelet Fatty Acid Composition and Protein Oxidation in Advanced Non-Small Cell Lung CancerCancer Investigation, 2006
- Increase in vulnerability to oxidative damage in cholesterol-modified erythrocytes exposed to t-BuOOHBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
- Validation of molecular and immunological factors with predictive importance in lung cancerLung Cancer, 2004
- Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lungFEBS Letters, 2004
- Structural Changes of the Erythrocyte as a Marker of Non-Insulin-Dependent Diabetes: Protective Effects of N-AcetylcysteineBiochemical and Biophysical Research Communications, 2002
- The association of fatty acids with prostate cancer riskThe Prostate, 2001
- Decrease of Polyunsaturated Fatty Acids and Elevation of the Oleic/Stearic Acid Ratio in Plasma and Red Blood Cell Lipids of Malnourished Cancer PatientsJournal of Parenteral and Enteral Nutrition, 1989