A Circuitous Route to Noncoding RNA
Open Access
- 26 April 2013
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 340 (6131), 440-441
- https://doi.org/10.1126/science.1238522
Abstract
Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered to be mostly “junk DNA.” Transcription is pervasive, however, and high-throughput sequencing has identified tens of thousands of distinct RNAs generated from the non—protein—coding portion of the genome (1). These so-called noncoding RNAs vary in length, but like protein-coding RNAs, appear to be linear molecules with 5′ and 3′ termini, reflecting the defined start and end points of RNA polymerase on the DNA template. But do all RNAs have to be linear?Keywords
This publication has 14 references indexed in Scilit:
- A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tailsGenes & Development, 2012
- Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell TypesPLOS ONE, 2012
- Transcriptome-wide discovery of circular RNAs in ArchaeaNucleic Acids Research, 2011
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cellsNature Methods, 2007
- Genome-wide transcription and the implications for genomic organizationNature Reviews Genetics, 2007
- Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAsScience, 1995
- Circular transcripts of the testis-determining gene Sry in adult mouse testisCell, 1993
- Mis-splicing yields circular RNA molecules.The FASEB Journal, 1993
- Structure, sequence and expression of the hepatitis delta (δ) viral genomeNature, 1986