Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization
- 25 November 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5752), 1340-1343
- https://doi.org/10.1126/science.1116894
Abstract
Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)–mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat.Keywords
This publication has 28 references indexed in Scilit:
- Dopamine-Dependent Interactions between Limbic and Prefrontal Cortical Plasticity in the Nucleus Accumbens: Disruption by Cocaine SensitizationNeuron, 2005
- Abstinence from Cocaine Self-Administration Heightens Neural Encoding of Goal-Directed Behaviors in the AccumbensNeuropsychopharmacology, 2005
- Unmanageable Motivation in Addiction: A Pathology in Prefrontal-Accumbens Glutamate TransmissionNeuron, 2005
- α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Subtype Glutamate Receptor (AMPAR) Endocytosis Is Essential for N-Methyl-D-aspartate-induced Neuronal ApoptosisPublished by Elsevier BV ,2004
- Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein InteractionsScience, 2002
- Addiction and the brain: The neurobiology of compulsion and its persistenceNature Reviews Neuroscience, 2001
- In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the MouseScience, 1999
- A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulantsBrain Research Reviews, 1997
- Synaptic plasticity: LTP and LTDCurrent Opinion in Neurobiology, 1994
- The neural basis of drug craving: An incentive-sensitization theory of addictionBrain Research Reviews, 1993