Efficient Approach To Discover Novel Agrochemical Candidates: Intermediate Derivatization Method
- 5 January 2015
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 64 (1), 45-51
- https://doi.org/10.1021/jf5054707
Abstract
Intensive competition of intellectual property, easy development of agrochemical resistance, and stricter regulations of environmental concerns make the successful rate for agrochemical discovery extremely lower using traditional agrochemical discovery methods. Therefore, there is an urgent need to find a novel approach to guide agrochemical discovery with high efficiency to quickly keep pace with the changing market. On the basis of these situations, here we summarize the intermediate derivatization method (IDM) between conventional methods in agrochemicals and novel ones in pharmaceuticals. This method is relatively efficient with short time in discovery phase, reduced cost, especially good innovated structure, and better performance. In this paper, we summarize and illustrate “what is the IDM” and “why to use” and “how to use” it to accelerate the discovery of new biologically active molecules, focusing on agrochemicals. Furthermore, we display several research projects in our novel agrochemical discovery programs with improved success rate under guidance of this strategy in recent years.This publication has 23 references indexed in Scilit:
- Current Challenges and Trends in the Discovery of AgrochemicalsScience, 2013
- Pesticide Exposure, Safety Issues, and Risk Assessment IndicatorsInternational Journal of Environmental Research and Public Health, 2011
- Design, synthesis and structure–activity relationship of novel coumarin derivativesPest Management Science, 2011
- Ammoxidation of 2,6-dichloro toluene—From first trials to pilot plant studiesCatalysis Today, 2010
- Design, synthesis and acaricidal activity of novel strobilurin derivatives containing pyrimidine moietiesPest Management Science, 2010
- Synthesis and insecticidal activity of novel 1-alkyl-3-sulfonyloxypyrazole-4-carboxamide derivativesJournal of Pesticide Science, 2010
- Synthesis and Biological Activity of New (E)-α-(Methoxyimino)benzeneacetate Derivatives Containing a Substituted Pyrazole RingJournal of Agricultural and Food Chemistry, 2009
- Innovation in Crop Protection: Trends in ResearchAngewandte Chemie, 2000
- Agrochemical Movement: Perspective and Scale-of-Study OverviewPublished by American Chemical Society (ACS) ,2000
- Biological activity of the new herbicide LGC-40863 {benzophenoneO-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime}Pesticide Science, 1997