Quantitative Sensory Testing in Painful Hand Osteoarthritis Demonstrates Features of Peripheral Sensitisation
Open Access
- 14 November 2012
- journal article
- research article
- Published by Hindawi Limited in International Journal of Rheumatology
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/703138
Abstract
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement, pain threshold in each hand joint, and radiological severity. We hypothesised that inflammation in hand osteoarthritis joints enhances sensitivity and firing of peripheral nociceptors, thereby causing chronic pain. Participants with proximal and distal interphalangeal (PIP and DIP) joint HOA and non-OA controls were recruited. Clinical parameters of joint involvement were measured including clinical nodes, VAS (visual analogue score) for pain (0–100 mm scale), HAQ (health assessment questionnaire), and Kellgren-Lawrence scores for radiological severity and pain threshold measurement were performed. The mean VAS in HOA participants was 59.3 mm ± 8.19 compared with 4.0 mm ± 1.89 in the control group (). Quantitative sensory testing (QST) demonstrated lower pain thresholds in DIP/PIP joints and other subgroups in the OA group including the thumb, metacarpophalangeal (MCPs), joints, and wrists () but not in controls (). Our data demonstrate that HOA subjects are sensitised to pain due to increased firing of peripheral nociceptors. Future work to evaluate mechanisms of peripheral sensitisation warrants further investigation.Keywords
This publication has 25 references indexed in Scilit:
- Dynamic, but not static, pain sensitivity predicts exercise-induced muscle pain: Covariation of temporal sensory summation and pain intensityNeuroscience Letters, 2012
- Effective Connectivity Among Brain Regions Associated With Slow Temporal Summation of C-Fiber-Evoked Pain in Fibromyalgia Patients and Healthy ControlsThe Journal of Pain, 2012
- Gender differences in outcomes of a multimodal pain management programPain, 2012
- What makes osteoarthritis painful? The evidence for local and central pain processingRheumatology, 2011
- Test–retest reliability of Quantitative Sensory Testing in knee osteoarthritis and healthy participantsOsteoarthritis and Cartilage, 2011
- Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritisRheumatology, 2010
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IIArthritis & Rheumatism, 2007
- EULAR evidence based recommendations for the management of hand osteoarthritis: Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)Annals Of The Rheumatic Diseases, 2007
- The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the handArthritis & Rheumatism, 1990
- Radiological Assessment of Osteo-ArthrosisAnnals Of The Rheumatic Diseases, 1957