Depression in people with type 2 diabetes: current perspectives
Open Access
- 31 December 2017
- journal article
- review article
- Published by Taylor & Francis Ltd in Diabetes, Metabolic Syndrome and Obesity
- Vol. 11, 333-343
- https://doi.org/10.2147/DMSO.S106797
Abstract
Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration. The latter considerations contribute to a "J-shaped" trajectory from the time of diagnosis. There remain significant challenges to screening for clinical risks associated with psychological symptoms in T2DM; poorer outcomes may be associated with major depressive episodes, isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like symptoms more specific to T2DM (eg, diabetes-related distress), apathy or fatigue. In this review, we discuss current perspectives on depression in the context of T2DM with implications for screening and management of these highly comorbid conditions.This publication has 128 references indexed in Scilit:
- Aspirin decreases the risk of depression in older men with high plasma homocysteineTranslational Psychiatry, 2012
- The bidirectional relationship of depression and diabetes: A systematic reviewClinical Psychology Review, 2011
- Antidepressant Medication Use and Risk of Hyperglycemia and Diabetes Mellitus—A Noncausal Association?Biological Psychiatry, 2011
- Electronic Health Records and Quality of Diabetes CareThe New England Journal of Medicine, 2011
- A Review of Treating Depression in Diabetes: Emerging FindingsPsychosomatics, 2011
- Reconsidering anhedonia in depression: Lessons from translational neuroscienceNeuroscience & Biobehavioral Reviews, 2011
- Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysisDiabetologia, 2010
- Fatigue in patients with diabetes: A reviewJournal of Psychosomatic Research, 2010
- Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort StudyJournal of General Internal Medicine, 2010
- The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementiaInternational Journal of Geriatric Psychiatry, 2008