Effect of Unilateral Dentate Nucleus Lesions on Amygdaloid Kindling in Rats
- 1 March 1992
- Vol. 33 (2), 213-221
- https://doi.org/10.1111/j.1528-1157.1992.tb02309.x
Abstract
Amygdala kindling is used to investigate cerebellar dentate nucleus participation in the neuronal plasticity of the cerebrum. We studied the behavioral change, the occurrence of epileptiform events, and the duration of afterdischarge during amygdaloid kindling under control conditions and after a dentate lesion of the contralateral cerebellum. Our results indicate that the dentate lesion induced the facilitation of the behavioral development of the amygdaloid kindling, whereas there was only a slight increase in the duration of afterdischarge and the spontaneous epileptiform potential of the amygdala. There was a discrepancy between the behavioral kindling and the electroencephalographic epileptic activity. Therefore the dentate lesion must play a role in controlling the generalization mechanism of epilepsy. We also found that on a right amygdala that had been influenced by a left dentate lesion there were few spikes, while on the left amygdala there were frequent spikes. These results suggest that the dentate nucleus plays an important role in amygdaloid kindling as well as in the neuronal plasticity of the amygdala.Keywords
This publication has 15 references indexed in Scilit:
- Midline thalamic lesion and feline amygdaloid kindling. I. Effect of lesion placement prior to kindlingElectroencephalography and Clinical Neurophysiology, 1988
- Divergent axon collaterals to cerebellum and amygdala from neurons in the parabrachial nucleus, the nucleus locus coeruleus and some adjacent nucleiBrain Structure and Function, 1985
- Hypothalamo-Cerebellar and Cerebello-Hypothalamic Pathways: A Review and Hypothesis Concerning Cerebellar Circuits Which May Influence Autonomic Centers and Affective BehaviorBrain, Behavior and Evolution, 1984
- Inputs and Outputs of the Amygdala: What the Amygdala is Trying to Tell the Rest of the BrainPublished by Springer Science and Business Media LLC ,1978
- Electrode placement and kindling-induced experiemental epilepsyExperimental Neurology, 1978
- Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: Evoked potential and histological studies in monkeys and catsExperimental Neurology, 1974
- Modification of seizure activity by electrical stimulation: II. Motor seizureElectroencephalography and Clinical Neurophysiology, 1972
- A permanent change in brain function resulting from daily electrical stimulationExperimental Neurology, 1969
- Development of Epileptic Seizures through Brain Stimulation at Low IntensityNature, 1967
- The Cerebellum as a Neuronal MachinePublished by Springer Science and Business Media LLC ,1967