Aberrant interhemispheric functional and structural connectivity in heroin‐dependent individuals
- 9 March 2016
- journal article
- Published by Wiley in Addiction Biology
- Vol. 22 (4), 1057-1067
- https://doi.org/10.1111/adb.12387
Abstract
Models of heroin addiction emphasize the role of disrupted frontostriatal circuitry supporting cognitive control processes. However, heroin addiction-related alterations in functional and structural interactions among brain regions, especially between the cerebral hemispheres, are rarely examined directly. Resting-state functional magnetic resonance imaging (fMRI) approaches, which reveal patterns of coherent spontaneous fluctuations in the fMRI signal, offer a means to quantify directly functional interactions between the hemispheres. The corpus callosum (CC), which connects homologous regions of the cortex, is the major conduit for information transfer between the cerebral hemispheres and represents a structural connectivity index between hemispheres. We compared interhemispheric voxel-mirrored homotopic connectivity (VMHC) and CC volume between 45 heroin dependent-individuals (HDIs) and 35 non-addict individuals. We observed significant reduction of VMHC in a number of regions, particularly the striatum/limbic system regions, and significant decrease in splenium and genu sub-regions of CC in HDI. Importantly, within HDI, VMHC in the dorsal lateral prefrontal cortex (DLPFC) correlated with genu CC volume, VMHC in the putamen, VMHC in the DLPFC and genu CC volume and splenium CC volume were negatively correlated with heroin duration and impulsivity traits. Further analyses demonstrated that impairment of VMHC of bilateral DLPFC partially mediated the association between genu CC volumes decreased and increased impulsivity in HDI. Our results reveal a substantial impairment of interhemispheric coordination in the HDI. Further, interhemispheric connectivity correlated with the duration of heroin abuse and higher impulsivity behavior in HDI. Our findings provide insight into a heroin addicts' related pathophysiology and reinforce an integrative view of the interhemispheric cerebral functional and structural organization.Keywords
Funding Information
- Natural Scientific Foundation of China (81201084, 81560283)
- Natural Scientific Foundation of Jiangxi Province, China (20151BAB205049)
- Planned Science and Technology Project of Guangdong Province (2011B031800044)
This publication has 47 references indexed in Scilit:
- Causal effect of disconnection lesions on interhemispheric functional connectivity in rhesus monkeysProceedings of the National Academy of Sciences, 2013
- Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive ControlNeuropsychopharmacology, 2013
- Progressive White Matter Microstructure Damage in Male Chronic Heroin Dependent Individuals: A DTI and TBSS StudyPLOS ONE, 2013
- FreeSurferNeuroImage, 2012
- Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implicationsNature Reviews Neuroscience, 2011
- Reduced Interhemispheric Resting State Functional Connectivity in Cocaine AddictionBiological Psychiatry, 2011
- Striatal dopamine D2 receptor availability predicts the thalamic and medial prefrontal responses to reward in cocaine abusers three years laterSynapse, 2009
- Addiction related alteration in resting-state brain connectivityNeuroImage, 2009
- Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis usersNeuroImage, 2009
- Imaging dopamine's role in drug abuse and addictionNeuropharmacology, 2008