Programmable on-chip DNA compartments as artificial cells
- 15 August 2014
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 345 (6198), 829-832
- https://doi.org/10.1126/science.1255550
Abstract
Toward an “artificial cell” on a chip: Cell-free systems that reconstitute biochemical pathways have been critical for unraveling the inner workings of the cell. Karzbrun et al. created a highly miniaturized cell-free system on a silicon chip. A series of tiny linked compartments were fabricated on the chip, in which DNA-driven reactions occurred, with materials flowing into and diffusing between the compartments. The system recreated oscillating protein expression patterns and protein gradients, and provides a stepping stone to creating “artificial cells” on a chip. Science , this issue p. 829Keywords
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