Drug diffusion from polymer core–shell nanoparticles
- 22 October 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Soft Matter
- Vol. 3 (12), 1513-1517
- https://doi.org/10.1039/b712514c
Abstract
Polymer core–shell nanoparticles are attractive drug-delivery systems because the drug can be encapsulated inside the core, while the shell properties can be assigned to optimise drug-delivery needs. An elegant approach to such particles is to use polymer gels, which have swelling properties that depend upon conditions such as pH. In this way swelling of the shell, and the drug release, can be targeted to occur at the desired location. We use computer simulations to capture the deformation of polymer core–shell nanoparticles and, subsequently, the drug diffusion from the core of these structures. In particular, we investigate the effects of shell swelling on drug-release rates, where the expanding shell leaves more free space for the drug to diffuse out of the core. Furthermore, we introduce enthalpic interactions and investigate both the physical and chemical barriers to drug release. Therefore, through a combination of structural and fluid simulations we can capture the physics of polymer core–shell nanoparticles and their uses for drug delivery.Keywords
This publication has 33 references indexed in Scilit:
- “Bending to Stretching” Transition in Disordered NetworksPhysical Review Letters, 2007
- Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systemsAdvanced Drug Delivery Reviews, 2006
- Hydrogels in controlled release formulations: Network design and mathematical modelingAdvanced Drug Delivery Reviews, 2006
- POLYMERIC CORE‐SHELL NANOPARTICLES FOR THERAPEUTICSClinical and Experimental Pharmacology and Physiology, 2006
- Influence of Shell Thickness and Cross-Link Density on the Structure of Temperature-Sensitive Poly-N-Isopropylacrylamide−Poly-N-Isopropylmethacrylamide Core−Shell Microgels Investigated by Small-Angle Neutron ScatteringLangmuir, 2005
- Recent developments in the formation, characterization, and simulation of micron and nano-scale droplets of amorphous polymer blends and semi-crystalline polymersPolymer, 2003
- Observation of the Volume Transition in Thermosensitive Core−Shell Latex Particles by Small-Angle X-ray ScatteringMacromolecules, 1998
- The neuroleptic activity of haloperidol increases after its solubilization in surfactant micellesFEBS Letters, 1989
- The organ uptake of intravenously administered colloidal particles can be altered using a non‐ionic surfactant (Poloxamer 338)FEBS Letters, 1984
- Theory of Solutions of High Polymers1Journal of the American Chemical Society, 1942