Synthesis of Optically Active Vomifoliol and Roseoside Stereoisomers
- 1 January 2005
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 53 (5), 541-546
- https://doi.org/10.1248/cpb.53.541
Abstract
A synthesis of optically active vomifoliol stereoisomers 1—4 and their glucosides, roseoside stereoisomers 5—8, was accomplished via α-acetylenic alcohol 11a or 11b effectively prepared by an asymmetric transfer hydrogenation of α,β-acetylenic ketone 10. Simultaneous separation of these stereoisomers by HPLC was also perfomed.Keywords
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