Lactacidosis in the neonate is minimized by prenatal detection of congenital heart disease
- 1 June 2002
- journal article
- Published by Wiley in Ultrasound in Obstetrics & Gynecology
- Vol. 19 (6), 552-555
- https://doi.org/10.1046/j.1469-0705.2002.00714.x
Abstract
To investigate the impact of prenatal detection of congenital heart disease on preventing severe preoperative lactacidosis. Patients operated upon for congenital heart disease during the first 31 days of life (n = 209) were studied retrospectively, 21 were diagnosed prenatally and 188 patients had not been diagnosed prenatally. Preoperative lactate, pH and base excess were evaluated. Differences were noted in preoperative pH (7.28 +/- 0.03 vs. 7.24 +/- 0.01, P = 0.29), base excess (-5.83 +/- 0.64 vs. -6.93 +/- 0.46 mmol/L, P = 0.10) and lactate (3.05 +/- 0.35 vs. 6.08 +/- 0.45 mmol/L, P < 0.001), indicating a significant difference in blood lactate values in favor of the prenatally diagnosed group. Prenatal diagnosis of congenital heart disease and the resulting immediate postnatal care prevent lactate increase in the preoperative period of these patients. This may decrease the risk of cerebral damage and result in the patient being in better condition at surgery.Keywords
This publication has 21 references indexed in Scilit:
- Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary reportPediatric Radiology, 1999
- Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of ageDevelopmental Medicine and Child Neurology, 1999
- Neurological morbidity after fetal supraventricular tachyarrhythmiaUltrasound in Obstetrics & Gynecology, 1999
- Recognition and Prevention of Neurological Complications in Pediatric Cardiac SurgeryPediatric Cardiology, 1998
- Effect of Prenatal Diagnosis of Critical Left Heart Obstruction on Perinatal Morbidity and MortalityAmerican Journal of Perinatology, 1998
- Does a prenatal diagnosis of congenital heart disease alter short-term outcome?Ultrasound in Obstetrics & Gynecology, 1997
- Initial postoperative serum lactate levels predict survival in children after open heart surgeryIntensive Care Medicine, 1996
- Mechanisms of ischemic brain damageCritical Care Medicine, 1988
- Congenital heart disease in the neonate: results of surgical treatment.Archives of Disease in Childhood, 1983
- E-type prostaglandins: a new emergency therapy for certain cyanotic congenital heart malformations.Circulation, 1976