Diversity of germ-line immunoglobulin VH genes
- 1 July 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 292 (5822), 426-430
- https://doi.org/10.1038/292426a0
Abstract
The sequences of 4 embryonic mouse Ig VH genes were compared. All genes end at codon 98 and code for a hydrophobic signal peptide of 19 residues interrupted at codon-4 by an intron of 83 base pairs. Substitutions occur in all gene segments but at a significantly higher frequency in the hypervariable regions. The data suggest an evolutionary basis for the diversity of Ig genes. Divergence resulted also in a termination codon in 2 of the genes, suggesting that part of the V gene repertoire cannot be expressed unless some correction mechanism is available.Keywords
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