Strand scission in DNA induced byl-DOPA in the presence of Cu(II)
- 1 May 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 364 (1), 75-78
- https://doi.org/10.1016/0014-5793(95)00365-g
Abstract
It has been recently reported that l-DOPA and Cu(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that l-DOPA in the presence of Cu(II) alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that l-DOPA is capable of binding to DNAKeywords
This publication has 25 references indexed in Scilit:
- Intense oxidative DNA damage promoted by l‐DOPA and its metabolites implications for neurodegenerative diseaseFEBS Letters, 1994
- Protein-bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteinsBiochemistry, 1993
- Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentrationZeitschrift für Neurologie, 1993
- The function of melanin or six blind people examine an elephantBioEssays, 1992
- [1] Role of free radicals and catalytic metal ions in human disease: An overviewMethods in enzymology, 1990
- DNA Single Strand Breakage by H2O2and Ferric or Cupric Ions: Its Modulation by HistidineFree Radical Research Communications, 1990
- Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicalsCarcinogenesis: Integrative Cancer Research, 1989
- Continuous Monitoring ofin VztroOxidation of Human Low Density LipoproteinFree Radical Research Communications, 1989
- LIPID PEROXIDATION AND THE CYTOTOXICITY OF COPPER*Annals of the New York Academy of Sciences, 1980
- [99] Determination of nucleic acids in tissues by pentose analysisMethods in Enzymology, 1957