Serum α1-Antitrypsin But Not Complement C3 and C4 Predicts Chronic Inflammation in Hemodialysis Patients
- 1 January 2003
- journal article
- research article
- Published by Informa UK Limited in Renal Failure
- Vol. 25 (4), 589-593
- https://doi.org/10.1081/jdi-120022550
Abstract
Background. We studied whether predialysis serum levels of positive acute phase markers such as α1-antitrypsin (AT), and complement components C3 and C4 could identify the presence of chronic inflammation in maintenance hemodialysis (HD) patients. Methods/Results. In 103 stable HD patients, AT directly correlated with C-reactive protein (CRP) (P1 acid-glycoprotein (PPPPP = 0.008) than that of 1.38 ± 0.27 g/L in the subjects with normal CRP and albumin. Using the above cut-off levels, the positive and negative predictive values of AT on the presence of severe inflammation were 0.86 and 0.62, respectively, and the sensitivity and specificity were 86% and 73%, respectively. Conclusion. Serum AT levels above 1.74 g/L and below 1.38 g/L may select the HD patients with severe inflammation from those without. Measurements of C3 and C4 are not helpful in this situation.Keywords
This publication has 11 references indexed in Scilit:
- Atherosclerotic Renal Artery StenosisJournal of the American Society of Nephrology, 2002
- Levels of α1 acid glycoprotein and ceruloplasmin predict future albumin levels in hemodialysis patientsKidney International, 2001
- Endothelial dysfunction marker von Willebrand factor antigen in haemodialysis patients: associations with pre‐dialysis blood pressure and the acute phase responseNephrology Dialysis Transplantation, 2001
- The Hematocrit-Corrected Erythrocyte Sedimentation Rate Can Be Useful in Diagnosing Inflammation in Hemodialysis PatientsNephron, 2001
- Cardiovascular disease determinants in chronic renal failure: clinical approach and treatmentNephrology Dialysis Transplantation, 2001
- Inflammatory and Atherosclerotic Interactions in the Depleted Uremic PatientBlood Purification, 2000
- C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patientsAmerican Journal of Kidney Diseases, 2000
- Acute-Phase Proteins and Other Systemic Responses to InflammationNew England Journal of Medicine, 1999
- Inflammation enhances cardiovascular risk and mortality in hemodialysis patientsKidney International, 1999
- Cardiovascular disease, fibrinogen and the acute phase response Associations with lipids and blood pressure in patients with chronic renal diseaseAtherosclerosis, 1998