Sex Differences in Hypertension: Where We Have Been and Where We Are Going
Top Cited Papers
- 12 November 2018
- journal article
- review article
- Published by Oxford University Press (OUP) in American Journal of Hypertension
- Vol. 31 (12), 1247-1254
- https://doi.org/10.1093/ajh/hpy148
Abstract
While it has been known since the 1940s that men have greater increases in blood pressure (BP) compared with women, there have been intense efforts more recently to increase awareness that women are also at risk for developing hypertension and that cardiovascular diseases (CVDs) are the leading causes of death among both men and women in the United States. With the release of the 2017 Hypertension Clinical Guidelines, 46% of adults in the United States are now classified as hypertensive, and hypertension is the primary modifiable risk factor for the development of CVD. This increase in the prevalence of hypertension is reflected in an increase in prevalence among both men and women across all demographics, although there were greater increases in the prevalence of hypertension among men compared with women. As a result, the well-established gender difference in the prevalence of hypertension is even more pronounced and now extends into the sixth decade of life. The goals of this review are to (i) review the historical clinical trial data and hypertension guidelines from the perspective of both genders and then (ii) review the role of the renin-angiotensin system and T-cell activation in contributing to sex differences in BP control.Funding Information
- National Institutes of Health (R0 HL127091, P01HL134604)
- American Heart Association (17EIA33410565)
This publication has 69 references indexed in Scilit:
- Is the renin–angiotensin system actually hypertensive?Pediatric Nephrology, 2013
- Differences Between Men and Women in Ambulatory Blood Pressure Thresholds for Diagnosis of Hypertension Based on Cardiovascular OutcomesChronobiology International, 2012
- Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive ratsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2012
- Natural Regulatory T Cells Control Coronary Arteriolar Endothelial Dysfunction in Hypertensive MiceThe American Journal of Pathology, 2011
- Angiotensin (1-7) Receptor Antagonism Equalizes Angiotensin II–Induced Hypertension in Male and Female Spontaneously Hypertensive RatsHypertension, 2010
- Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunctionThe Journal of Experimental Medicine, 2007
- Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidneyProceedings of the National Academy of Sciences of the United States of America, 2006
- Sex and the Renin Angiotensin System: Implications for Gender Differences in the Progression of Kidney DiseaseAdvances in Renal Replacement Therapy, 2003
- Baseline Characteristics and Early Blood Pressure Control in the CONVINCE TrialHypertension, 2001
- Possible Role of Renin in Hypertension as Suggested by Renin-Sodium Profiling and Inhibition of Converting EnzymeThe New England Journal of Medicine, 1977