Characterization of particle sizes in bulk pharmaceutical solids using digital image information
Open Access
- 1 December 2003
- journal article
- Published by Springer Science and Business Media LLC in AAPS PharmSciTech
- Vol. 4 (4), 383-391
- https://doi.org/10.1208/pt040449
Abstract
The purpose of this study was to demonstrate a novel method of extracting relevant information from undispersed bulk powder surfaces to be used in particle size analysis. A new surface imaging approach for undispersed powders combined with multivariate modeling was used. Digital surface images of various granule batches were captured using an inventive optical setup in controlled illumination conditions. A descriptor, the gray scale difference matrix (GSDM), which describes the particle size of granular material was generated and extracted from the powder surface image information. Partial least squares (PLS) modeling was used to create a model between the GSDM and the particle size distribution of granules measured with sieving. The use of lateral illumination and the combining of information from 2 surface images strengthened the shading effects on the powder surfaces. The shading effects exposed the topography or the visual texture of the powder surfaces. This textural information was efficiently extracted using the GSDM descriptor. The goodness-of-fit (R2) for the created PLS model was 0.91 and the predicted variation (Q2) was 0.87, indicating a good model. The model covered granule sizes in the size range of approximately 20 to 2500 microm. The extracted descriptor was effectively used in particle size measurement. This study confirms that digital images taken from undispersed bulk powder surfaces contain substantial information needed for particle size distribution analysis. The use of the GSDM enabled the utilization of bulk powder surface information and provided a fast method for particle size measurement.Keywords
This publication has 14 references indexed in Scilit:
- Does a powder surface contain all necessary information for particle size distribution analysis?European Journal of Pharmaceutical Sciences, 2002
- Characterization of Bulk Particles in Real TimeParticle & Particle Systems Characterization, 2002
- A calibration procedure to obtain solid concentrations from digital images of bulk powdersPowder Technology, 2001
- Content-Based Image Retrieval: A New Promising Technique in Powder TechnologyPharmaceutical Development and Technology, 2000
- Particle morphology: from visualisation to measurementPowder Technology, 1999
- Particle size characterisation of in-flow milling products by video image analysis using global featuresJournal of the Science of Food and Agriculture, 1998
- Query by image and video content: the QBIC systemComputer, 1995
- Efficient and effective Querying by Image ContentJournal of Intelligent Information Systems, 1994
- Particle Size Analysis In Pharmaceutics And Other Industries: Theory And PracticePublished by Informa UK Limited ,1992
- Microscopic Characterization of Particle Size and Shape: An Inexpensive and Versatile MethodPharmaceutical Research, 1992