An Angiotensin Converting-Enzyme Inhibitor to Identify and Treat Vasoconstrictor and Volume Factors in Hypertensive Patients
- 17 October 1974
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 291 (16), 817-821
- https://doi.org/10.1056/nejm197410172911603
Abstract
The antihypertensive action of nonapeptide competitive inhibitor of angiotensin-1-converting enzyme was evaluated in 13 hypertensive patients. In 12 a single injection (1 to 4 mg per kilogram) induced an immediate antihypertensive effect that lasted, depending on dose, up to 16 hours. Mean diastolic pressures (±S.E.) fell from 126±3 to 101±4 mm Hg. Plasma renin increased and aldosterone fell.Keywords
This publication has 9 references indexed in Scilit:
- ANGIOTENSIN-II BLOCKADE IN MAN BY SAR1-ALA8-ANGIOTENSIN II FOR UNDERSTANDING AND TREATMENT OF HIGH BLOOD-PRESSUREThe Lancet, 1973
- Hypertension in chronic renal failure: An abnormal relation between sodium and the renin-angiotensin systemAmerican Journal Of Medicine, 1973
- Antihypertensive action of propranolol: Specific antirenin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertensionThe American Journal of Cardiology, 1973
- Vasoconstriction-volume analysis for understanding and treating hypertension: The use of renin and aldosterone profilesAmerican Journal Of Medicine, 1973
- Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive RatsScience, 1973
- REDUCTION OF PRESSOR EFFECTS OF ANGIOTENSIN I IN MAN BY SYNTHETIC NONAPEPTIDE (B.P.P.9a OR SQ 20,881) WHICH INHIBITS CONVERTING ENZYMEThe Lancet, 1973
- Inhibition of Angiotensin Conversion in Experimental Renovascular HypertensionScience, 1972
- Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesisBiochemistry, 1971
- POTENTIAL SCREENING TEST FOR DETECTION OF OVERACTIVITY OF RENIN-ANGIOTENSIN SYSTEMThe Lancet, 1971