The 2004 WHO Classification of Bladder Tumors: A Summary and Commentary
- 1 April 2005
- journal article
- review article
- Published by SAGE Publications in International Journal of Surgical Pathology
- Vol. 13 (2), 143-153
- https://doi.org/10.1177/106689690501300203
Abstract
The key points of the latest World Health Organization (WHO) classification of noninvasive urothelial tumors are the following: the description of the categories has been expanded to improve their recognition; a tumor with particularly good prognosis (papillary urothelial neoplasm of low malignant potential) no longer carries the label of ‘cancer’; it avoids the use of ambiguous grading such as grade 1/2 or 2/3 (as done in the 1973 WHO classification); the group of noninvasive high-grade carcinoma is large enough to virtually contain all those tumors having biological properties similar to those seen in invasive urothelial carcinoma, and a similarly high level of genetic instability. This scheme is meant to replace the 1973 WHO classification, but the use of both the 1973 and the latest WHO classifications is recommended until the latter is sufficiently validated.Keywords
This publication has 29 references indexed in Scilit:
- Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma1 1The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the University of Ancona or the National Cancer Institute.Human Pathology, 2003
- Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversiesJournal of Clinical Pathology, 2003
- The pagetoid variant of bladder urothelial carcinoma in situVirchows Archiv, 2002
- Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International ConsultationVirchows Archiv, 2001
- Morphologic Expressions of Urothelial Carcinoma In SituThe American Journal of Surgical Pathology, 2001
- Assessment of basal cell status andproliferative patterns in flat and papillary urothelial lesions: A contribution to the new who classification of urothelial tumors of the urinary bladderHuman Pathology, 2000
- Natural History of Urothelial Dysplasia of the BladderThe American Journal of Surgical Pathology, 1999
- Frequent Genetic Alterations in Simple Urothelial Hyperplasias of the Bladder in Patients with Papillary Urothelial CarcinomaThe American Journal of Pathology, 1999
- The World Health Organization/International Society of Urological Pathology Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary BladderThe American Journal of Surgical Pathology, 1998
- Cytokeratin 20 as an objective marker of urothelial dysplasiaPublished by Wiley ,1996